4DT7
Crystal structure of thrombin bound to the activation domain QEDQVDPRLIDGKMTRRGDS of protein C
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Thrombin light chain | polymer | 32 | 3704.1 | 2 | UniProt (P00734) Pfam (PF09396) | Homo sapiens (human) | |
| 2 | B, D (B, D) | Thrombin heavy chain | polymer | 259 | 29764.2 | 2 | UniProt (P00734) Pfam (PF00089) | Homo sapiens (human) | |
| 3 | E, F (E, F) | Vitamin K-dependent protein C | polymer | 20 | 2320.5 | 2 | UniProt (P04070) | Homo sapiens | Anticoagulant protein C, Autoprothrombin IIA, Blood coagulation factor XIV, Vitamin K-dependent protein C light chain, Vitamin K-dependent protein C heavy chain, Activation peptide |
| 4 | G, K (B, D) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 5 | H (B) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 6 | I, J (B, D) | ACETATE ION | non-polymer | 59.0 | 2 | Chemie (ACT) | |||
| 7 | L, M, N, O, P... (A, B, C, D, E...) | water | water | 18.0 | 326 | Chemie (HOH) |
Sequence modifications
B, D: 16 - 247 (UniProt: P00734)
| PDB | External Database | Details |
|---|---|---|
| Ala 195 | Ser 568 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 71577.8 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 270.2 | |
| All* | Total formula weight | 71848.0 |
