4DST

Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity

4DST の概要

• エントリーDOI: 10.2210/pdb4dst/pdb
• 関連するPDBエントリー: 4DSN 4DSO 4DSU
• 分子名称: GTPase KRas, isoform 2B, 2-(4,6-dichloro-2-methyl-1H-indol-3-yl)ethanamine, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ... (9 entities in total)
• 機能のキーワード: small g-protein, signaling, hydrolase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cell membrane; Lipid-anchor; Cytoplasmic side: P01116
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 22634.86

構造登録者

Oh, A.,Maurer, T.,Garrenton, L.S.,Pitts, K.,Anderson, D.J.,Skelton, N.J.,Fauber, B.P.,Pan, B.,Malek, S.,Stokoe, D.,Ludlam, M.,Bowman, K.K.,Wu, J.,Giannetti, A.M.,Starovasnik, M.A.,Mellman, I.,Jackson, P.K.,Ruldolph, J.,Fang, G.,Wang, W. (登録日: 2012-02-19, 公開日: 2012-04-04, 最終更新日: 2024-02-28)

• 主引用文献: Maurer, T.,Garrenton, L.S.,Oh, A.,Pitts, K.,Anderson, D.J.,Skelton, N.J.,Fauber, B.P.,Pan, B.,Malek, S.,Stokoe, D.,Ludlam, M.J.,Bowman, K.K.,Wu, J.,Giannetti, A.M.,Starovasnik, M.A.,Mellman, I.,Jackson, P.K.,Rudolph, J.,Wang, W.,Fang, G.; Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity.; Proc.Natl.Acad.Sci.USA, 109:5299-5304, 2012; PubMed: 22431598; DOI: 10.1073/pnas.1116510109

実験手法

X-RAY DIFFRACTION (2.3 Å)