4DSU

Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity

Summary for 4DSU

Entry DOI	10.2210/pdb4dsu/pdb
Related	4DSN 4DSO 4DST
Descriptor	GTPase KRas, isoform 2B, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	small g-protein, signaling, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Cell membrane; Lipid-anchor; Cytoplasmic side: P01116
Total number of polymer chains	1
Total formula weight	22116.22
Authors	Oh, A.,Maurer, T.,Garrenton, L.S.,Pitts, K.,Anderson, D.J.,Skelton, N.J.,Fauber, B.P.,Pan, B.,Malek, S.,Stokoe, D.,Ludlam, M.,Bowman, K.K.,Wu, J.,Giannetti, A.M.,Starovasnik, M.A.,Mellman, I.,Jackson, P.K.,Ruldolph, J.,Fang, G.,Wang, W. (deposition date: 2012-02-19, release date: 2012-04-04, Last modification date: 2024-02-28)
Primary citation	Maurer, T.,Garrenton, L.S.,Oh, A.,Pitts, K.,Anderson, D.J.,Skelton, N.J.,Fauber, B.P.,Pan, B.,Malek, S.,Stokoe, D.,Ludlam, M.J.,Bowman, K.K.,Wu, J.,Giannetti, A.M.,Starovasnik, M.A.,Mellman, I.,Jackson, P.K.,Rudolph, J.,Wang, W.,Fang, G. Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity. Proc.Natl.Acad.Sci.USA, 109:5299-5304, 2012 Cited by PubMed: 22431598 DOI: 10.1073/pnas.1116510109 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation