4DRM
EVALUATION OF SYNTHETIC FK506 ANALOGS AS LIGANDS FOR FKBP51 AND FKBP52: COMPLEX OF FKBP51 WITH {3-[(1R)-3-(3,4-dimethoxyphenyl)-1-({[(2S)-1-{[(1S,2R)-2-ethyl-1-hydroxycyclohexyl](oxo)acetyl}piperidin-2-yl]carbonyl}oxy)propyl]phenoxy}acetic acid
Summary for 4DRM
Entry DOI | 10.2210/pdb4drm/pdb |
Related | 4DRK 4DRN 4DRO 4DRP 4DRQ |
Descriptor | Peptidyl-prolyl cis-trans isomerase FKBP5, {3-[(1R)-3-(3,4-dimethoxyphenyl)-1-({[(2S)-1-{[(1S,2R)-2-ethyl-1-hydroxycyclohexyl](oxo)acetyl}piperidin-2-yl]carbonyl}oxy)propyl]phenoxy}acetic acid (3 entities in total) |
Functional Keywords | fk-506 binding domain, hsp90 cochaperone, immunophilin, peptidyl-prolyl isomerase, isomerase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: Q13451 |
Total number of polymer chains | 1 |
Total formula weight | 14665.81 |
Authors | Gopalakrishnan, R.,Kozany, C.,Gaali, S.,Kress, C.,Hoogeland, B.,Bracher, A.,Hausch, F. (deposition date: 2012-02-17, release date: 2012-05-16, Last modification date: 2023-09-13) |
Primary citation | Gopalakrishnan, R.,Kozany, C.,Gaali, S.,Kress, C.,Hoogeland, B.,Bracher, A.,Hausch, F. Evaluation of Synthetic FK506 Analogues as Ligands for the FK506-Binding Proteins 51 and 52. J.Med.Chem., 55:4114-4122, 2012 Cited by PubMed: 22455444DOI: 10.1021/jm201746x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.48 Å) |
Structure validation
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