4DQF
Crystal Structure of (G16A/L38A) HIV-1 Protease in Complex with DRV
Summary for 4DQF
Entry DOI | 10.2210/pdb4dqf/pdb |
Related | 4DQB 4DQC 4DQE 4DQG 4DQH |
Descriptor | Aspartyl protease, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, SULFATE ION, ... (6 entities in total) |
Functional Keywords | hiv-1 protease, drug resistance, drug design, protease inhibitors, aids, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Human immunodeficiency virus 1 (HIV-1) |
Total number of polymer chains | 2 |
Total formula weight | 22373.25 |
Authors | Schiffer, C.A.,Mittal, S. (deposition date: 2012-02-15, release date: 2012-03-07, Last modification date: 2024-02-28) |
Primary citation | Mittal, S.,Cai, Y.,Nalam, M.N.,Bolon, D.N.,Schiffer, C.A. Hydrophobic core flexibility modulates enzyme activity in HIV-1 protease. J.Am.Chem.Soc., 134:4163-4168, 2012 Cited by PubMed: 22295904DOI: 10.1021/ja2095766 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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