4DQ2

Structure of staphylococcus aureus biotin protein ligase in complex with biotinol-5'-amp

4DQ2 の概要

• エントリーDOI: 10.2210/pdb4dq2/pdb
• 分子名称: Biotin-[acetyl-CoA-carboxylase] ligase, ((2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXY-TETRAHYDROFURAN-2-YL)METHYL 5-((3AS,4S,6AR)-2-OXO-HEXAHYDRO-1H-THIENO[3,4-D]IMIDAZOL-4-YL)PENTYL HYDROGEN PHOSPHATE (3 entities in total)
• 機能のキーワード: dna binding domain, metabolism, biotin, ligate, ligase
• 由来する生物種: Staphylococcus aureus
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38443.17

構造登録者

Wilce, M.,Yap, M.,Pendini, N.,Soares de Costa, T.,Polyak, S.,Tieu, W.,Booker, G.,Wallace, J. (登録日: 2012-02-14, 公開日: 2012-04-18, 最終更新日: 2024-03-20)

• 主引用文献: Soares da Costa, T.P.,Tieu, W.,Yap, M.Y.,Pendini, N.R.,Polyak, S.W.,Sejer Pedersen, D.,Morona, R.,Turnidge, J.D.,Wallace, J.C.,Wilce, M.C.,Booker, G.W.,Abell, A.D.; Selective inhibition of biotin protein ligase from Staphylococcus aureus.; J.Biol.Chem., 287:17823-17832, 2012; PubMed: 22437830; DOI: 10.1074/jbc.M112.356576

実験手法

X-RAY DIFFRACTION (2.5 Å)