4DNO

Crystal structure of the CFTR inhibitory factor Cif with the E153Q mutation adducted with the 1,2-epoxyhexane hydrolysis intermediate

Summary for 4DNO

Entry DOI	10.2210/pdb4dno/pdb
Related	3KD2 3KDA 3PI6 4DLN 4DM7 4DMC 4DMF 4DMH 4DNF
Descriptor	Putative hydrolase, (2R)-hexane-1,2-diol (3 entities in total)
Functional Keywords	alpha beta hydrolase, epoxide hydrolase covalently adducted with the 1, 2-epoxyhexane hydrolysis intermediate, secreted, hydrolase
Biological source	Pseudomonas aeruginosa
Total number of polymer chains	4
Total formula weight	137127.56
Authors	Bahl, C.D.,Patankar, Y.R.,Madden, D.R. (deposition date: 2012-02-08, release date: 2013-08-07, Last modification date: 2023-09-13)
Primary citation	Bahl, C.D.,Hvorecny, K.L.,Morisseau, C.,Gerber, S.A.,Madden, D.R. Visualizing the Mechanism of Epoxide Hydrolysis by the Bacterial Virulence Enzyme Cif. Biochemistry, 55:788-797, 2016 Cited by PubMed: 26752215 DOI: 10.1021/acs.biochem.5b01229 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation