4DLD
Crystal structure of the GluK1 ligand-binding domain (S1S2) in complex with the antagonist (S)-2-amino-3-(2-(2-carboxyethyl)-5-chloro-4-nitrophenyl)propionic acid at 2.0 A resolution
Summary for 4DLD
Entry DOI | 10.2210/pdb4dld/pdb |
Related | 3TZA |
Descriptor | Glutamate receptor, ionotropic kainate 1, (S)-2-amino-3-(2-(2-carboxyethyl)-5-chloro-4-nitrophenyl)propionic acid, CHLORIDE ION, ... (6 entities in total) |
Functional Keywords | ionotropic glutamate receptor, glutamate, membrane, membrane protein |
Biological source | Rattus norvegicus (rat) More |
Cellular location | Cell membrane; Multi-pass membrane protein: P22756 |
Total number of polymer chains | 2 |
Total formula weight | 59073.90 |
Authors | Venskutonyte, R.,Frydenvang, K.,Kastrup, J.S. (deposition date: 2012-02-06, release date: 2012-10-10, Last modification date: 2023-11-08) |
Primary citation | Venskutonyte, R.,Frydenvang, K.,Valades, E.A.,Szymanska, E.,Johansen, T.N.,Kastrup, J.S.,Pickering, D.S. Structural and pharmacological characterization of phenylalanine-based AMPA receptor antagonists at kainate receptors Chemmedchem, 7:1793-1798, 2012 Cited by PubMed: 22407805DOI: 10.1002/cmdc.201100599 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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