4DL1

Crystal Structure of human Myeloperoxidase with covalent thioxanthine analog

Summary for 4DL1

Entry DOI	10.2210/pdb4dl1/pdb
Descriptor	Myeloperoxidase light chain, Myeloperoxidase heavy chain, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
Functional Keywords	oxidoreductase, heme-dependent peroxidase
Biological source	Homo sapiens (human) More
Total number of polymer chains	16
Total formula weight	541355.54
Authors	Vajdos, F.,Varghese, A. (deposition date: 2012-02-05, release date: 2012-03-21, Last modification date: 2020-07-29)
Primary citation	Geoghegan, K.F.,Varghese, A.H.,Feng, X.,Bessire, A.J.,Conboy, J.J.,Ruggeri, R.B.,Ahn, K.,Spath, S.N.,Filippov, S.V.,Conrad, S.J.,Carpino, P.A.,Guimaraes, C.R.,Vajdos, F.F. Deconstruction of activity-dependent covalent modification of heme in human neutrophil myeloperoxidase by multistage mass spectrometry (MS(4)). Biochemistry, 51:2065-2077, 2012 Cited by PubMed: 22352991 DOI: 10.1021/bi201872j PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation