4DJO

Crystal Structure of wild-type HIV-1 Protease in Complex with MKP56

4DJO の概要

• エントリーDOI: 10.2210/pdb4djo/pdb
• 関連するPDBエントリー: 4DJP 4DJQ 4DJR
• 分子名称: Pol polyprotein, 2-[(dichloroacetyl)amino]ethyl [(2S,3R)-3-hydroxy-4-{[(4-methoxyphenyl)sulfonyl][(2S)-2-methylbutyl]amino}-1-phenylbutan-2-yl]carbamate, GLYCEROL, ... (6 entities in total)
• 機能のキーワード: hiv-1 protease, drug resistance, drug design, protease inhibitors, aids, aspartyl protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Human immunodeficiency virus 1
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22591.23

構造登録者

Schiffer, C.A.,Nalam, M.N.L. (登録日: 2012-02-02, 公開日: 2012-08-01, 最終更新日: 2024-02-28)

• 主引用文献: Parai, M.K.,Huggins, D.J.,Cao, H.,Nalam, M.N.,Ali, A.,Schiffer, C.A.,Tidor, B.,Rana, T.M.; Design, synthesis, and biological and structural evaluations of novel HIV-1 protease inhibitors to combat drug resistance.; J.Med.Chem., 55:6328-6341, 2012; PubMed: 22708897; DOI: 10.1021/jm300238h

実験手法

X-RAY DIFFRACTION (1.78 Å)