4DJR
Crystal Structure of wild-type HIV-1 Protease in Complex with MKP97
Summary for 4DJR
Entry DOI | 10.2210/pdb4djr/pdb |
Related | 4DJO 4DJP 4DJQ |
Descriptor | Pol polyprotein, [(2S)-5-oxopyrrolidin-2-yl]methyl [(2S,3R)-4-{(1,3-benzothiazol-6-ylsulfonyl)[(2S)-2-methylbutyl]amino}-3-hydroxy-1-phenylbutan-2-yl]carbamate, PHOSPHATE ION, ... (4 entities in total) |
Functional Keywords | hiv-1 protease, drug resistance, drug design, protease inhibitors, aids, aspartyl protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Human immunodeficiency virus 1 |
Total number of polymer chains | 2 |
Total formula weight | 22505.23 |
Authors | Schiffer, C.A.,Nalam, M.N.L. (deposition date: 2012-02-02, release date: 2012-08-01, Last modification date: 2024-02-28) |
Primary citation | Parai, M.K.,Huggins, D.J.,Cao, H.,Nalam, M.N.,Ali, A.,Schiffer, C.A.,Tidor, B.,Rana, T.M. Design, synthesis, and biological and structural evaluations of novel HIV-1 protease inhibitors to combat drug resistance. J.Med.Chem., 55:6328-6341, 2012 Cited by PubMed: 22708897DOI: 10.1021/jm300238h PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.55 Å) |
Structure validation
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