4DED

Aurora A in complex with YL1-038-21

Summary for 4DED

Entry DOI	10.2210/pdb4ded/pdb
Related	4DEA 4DEB 4DEE
Descriptor	Aurora kinase A, 2-({2-[(4-carbamoylphenyl)amino]pyrimidin-4-yl}amino)benzamide, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	protein kinase, aurora a, dfg-in, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm, cytoskeleton, centrosome: O14965
Total number of polymer chains	1
Total formula weight	32893.69
Authors	Martin, M.P.,Zhu, J.-Y.,Schonbrunn, E. (deposition date: 2012-01-20, release date: 2012-08-22, Last modification date: 2023-09-13)
Primary citation	Lawrence, H.R.,Martin, M.P.,Luo, Y.,Pireddu, R.,Yang, H.,Gevariya, H.,Ozcan, S.,Zhu, J.Y.,Kendig, R.,Rodriguez, M.,Elias, R.,Cheng, J.Q.,Sebti, S.M.,Schonbrunn, E.,Lawrence, N.J. Development of o-Chlorophenyl Substituted Pyrimidines as Exceptionally Potent Aurora Kinase Inhibitors. J.Med.Chem., 55:7392-7416, 2012 Cited by PubMed: 22803810 DOI: 10.1021/jm300334d PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.05 Å)

Structure validation