4DD8

ADAM-8 metalloproteinase domain with bound batimastat

Summary for 4DD8

Entry DOI	10.2210/pdb4dd8/pdb
Descriptor	Disintegrin and metalloproteinase domain-containing protein 8, 4-(N-HYDROXYAMINO)-2R-ISOBUTYL-2S-(2-THIENYLTHIOMETHYL)SUCCINYL-L-PHENYLALANINE-N-METHYLAMIDE, CALCIUM ION, ... (8 entities in total)
Functional Keywords	batimastat, inflammation, alpha/beta motif, metalloproteinase, allergic asthma, tumorigenesis, arthritis, aberrant neural cell signaling, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Membrane; Single-pass type I membrane protein: P78325
Total number of polymer chains	4
Total formula weight	96153.62
Authors	Hall, T.,Shieh, H.S.,Day, J.E.,Caspers, N.,Chrencik, J.E.,Williams, J.M.,Pegg, L.E.,Pauley, A.M.,Moon, A.F.,Krahn, J.M.,Fischer, D.H.,Kiefer, J.R.,Tomasselli, A.G.,Zack, M.D. (deposition date: 2012-01-18, release date: 2012-06-06, Last modification date: 2023-09-13)
Primary citation	Hall, T.,Shieh, H.S.,Day, J.E.,Caspers, N.,Chrencik, J.E.,Williams, J.M.,Pegg, L.E.,Pauley, A.M.,Moon, A.F.,Krahn, J.M.,Fischer, D.H.,Kiefer, J.R.,Tomasselli, A.G.,Zack, M.D. Structure of human ADAM-8 catalytic domain complexed with batimastat. Acta Crystallogr.,Sect.F, 68:616-621, 2012 Cited by PubMed: 22684055 DOI: 10.1107/S1744309112015618 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation