4DCH

Insights into Glucokinase Activation Mechanism: Observation of Multiple Distinct Protein Conformations

4DCH の概要

• エントリーDOI: 10.2210/pdb4dch/pdb
• 分子名称: Glucokinase, alpha-D-glucopyranose, (2R)-3-cyclopentyl-2-[4-(methylsulfonyl)phenyl]-N-(1,3-thiazol-2-yl)propanamide, ... (5 entities in total)
• 機能のキーワード: gk beta cell, small molecule, open conformation, kinase, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 54142.03

構造登録者

Greasley, S.E.,Hickey, M.,Feng, J.,Garcia, E. (登録日: 2012-01-17, 公開日: 2012-02-08, 最終更新日: 2024-02-28)

• 主引用文献: Liu, S.,Ammirati, M.J.,Song, X.,Knafels, J.D.,Zhang, J.,Greasley, S.E.,Pfefferkorn, J.A.,Qiu, X.; Insights into Mechanism of Glucokinase Activation: OBSERVATION OF MULTIPLE DISTINCT PROTEIN CONFORMATIONS.; J.Biol.Chem., 287:13598-13610, 2012; PubMed: 22298776; DOI: 10.1074/jbc.M111.274126

実験手法

X-RAY DIFFRACTION (1.79 Å)