4DAG
Structure of the Human Metapneumovirus Fusion Protein with Neutralizing Antibody Identifies a Pneumovirus Antigenic Site
Summary for 4DAG
| Entry DOI | 10.2210/pdb4dag/pdb |
| Descriptor | Fusion glycoprotein F0, Neutralizing Antibody DS7 heavy chain, Neutralizing Antibody DS7 light chain, ... (4 entities in total) |
| Functional Keywords | viral protein, mpv fusion protein, antibody, immune system, ds7 antibody structure, ds7, fab structure, vaccine, viral protein-immune system complex, viral protein/immune system |
| Biological source | Human metapneumovirus More |
| Total number of polymer chains | 3 |
| Total formula weight | 92414.73 |
| Authors | Jardetzky, T.S.,Wen, X. (deposition date: 2012-01-12, release date: 2012-02-29, Last modification date: 2024-11-20) |
| Primary citation | Wen, X.,Krause, J.C.,Leser, G.P.,Cox, R.G.,Lamb, R.A.,Williams, J.V.,Crowe, J.E.,Jardetzky, T.S. Structure of the human metapneumovirus fusion protein with neutralizing antibody identifies a pneumovirus antigenic site. Nat.Struct.Mol.Biol., 19:461-463, 2012 Cited by PubMed Abstract: Human metapneumovirus and respiratory syncytial virus cause lower respiratory tract infections. The virus fusion (F) glycoprotein promotes membrane fusion by refolding from a metastable pre-fusion to a stable post-fusion conformation. F is also a major target of the neutralizing antibody response. Here we show that a potently neutralizing anti-human metapneumovirus antibody (DS7) binds a structurally invariant domain of F, revealing a new epitope that could be targeted in vaccine development. PubMed: 22388735DOI: 10.1038/nsmb.2250 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.3904 Å) |
Structure validation
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