4DAG

Structure of the Human Metapneumovirus Fusion Protein with Neutralizing Antibody Identifies a Pneumovirus Antigenic Site

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Fusion glycoprotein F0	polymer	415	44946.2	1	UniProt (G3KCK8) Pfam (PF00523)	Human metapneumovirus
2	B (H)	Neutralizing Antibody DS7 heavy chain	polymer	220	23109.0	1	UniProt (P01857) Pfam (PF07654)	Homo sapiens (human)
3	C (L)	Neutralizing Antibody DS7 light chain	polymer	213	22537.8	1	UniProt (Q8N5F4) Pfam (PF07686) Pfam (PF07654)	Homo sapiens (human)
4	D, E (B, C)	alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		910.8	2	In PDB GlyTouCan (G22768VO)

Sequence modifications

H: 1 - 139 (PDB: 4DAG)
H: 140 - 220 (UniProt: P01857)
L: 21 - 122 (PDB: 4DAG)
L: 123 - 232 (UniProt: Q8N5F4)

PDB	External Database	Details
Met 233	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	90593.1
Branched	Number of molecules	2
	Total formula weight	1821.6
All*	Total formula weight	92414.7

*Water molecules are not included.