4DA5

Choline Kinase alpha acts through a double-displacement kinetic mechanism involving enzyme isomerisation, as determined through enzyme and inhibitor kinetics and structural biology

4DA5 の概要

• エントリーDOI: 10.2210/pdb4da5/pdb
• 分子名称: Choline kinase alpha, SULFATE ION, (3R)-1-azabicyclo[2.2.2]oct-3-yl[bis(5-chlorothiophen-2-yl)]methanol, ... (4 entities in total)
• 機能のキーワード: kinase, signal transduction, cytoplasmic, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P35790
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 105562.56

構造登録者

Brown, K.,Hudson, C.,Charlton, P.,Pollard, J. (登録日: 2012-01-12, 公開日: 2013-04-17, 最終更新日: 2024-02-28)

• 主引用文献: Hudson, C.S.,Knegtel, R.M.,Brown, K.,Charlton, P.A.,Pollard, J.R.; Kinetic and mechanistic characterisation of Choline Kinase-alpha.; Biochim.Biophys.Acta, 1834:1107-1116, 2013; PubMed: 23416529; DOI: 10.1016/j.bbapap.2013.02.008

実験手法

X-RAY DIFFRACTION (2.4 Å)