4D7O

Structure of rat neuronal nitric oxide synthase heme domain in complex with 6-(4-(((3-Fluorophenethyl)amino)methyl)phenyl)-4- methylpyridin-2-amine

Summary for 4D7O

• Entry DOI: 10.2210/pdb4d7o/pdb
• Descriptor: NITRIC OXIDE SYNTHASE, BRAIN, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total)
• Functional Keywords: oxidoreductase, nitric oxide synthase, inhibitor complex
• Biological source: RATTUS NORVEGICUS (NORWAY RAT)
• Cellular location: Cell membrane, sarcolemma ; Peripheral membrane protein : P29476
• Total number of polymer chains: 2
• Total formula weight: 100194.86

Authors

Li, H.,Poulos, T.L. (deposition date: 2014-11-25, release date: 2015-07-01)

• Primary citation: Holden, J.K.,Kang, S.,Beasley, F.C.,Cinelli, M.A.,Li, H.,Roy, S.G.,Dejam, D.,Edinger, A.L.,Nizet, V.,Silverman, R.B.,Poulos, T.L.; Nitric Oxide Synthase as a Target for Methicillin-Resistant Staphylococcus Aureus; Chem.Biol., 22:785-, 2015; PubMed: 26091171; DOI: 10.1016/J.CHEMBIOL.2015.05.013

Experimental method

X-RAY DIFFRACTION (1.78 Å)