4D7G

Human FXIa in complex with small molecule inhibitors.

Summary for 4D7G

Entry DOI	10.2210/pdb4d7g/pdb
Related	4D76 4D7F
Descriptor	COAGULATION FACTOR XIA, GLYCEROL, N-[(1S)-1-benzyl-2-(3-guanidinopropylamino)-2-oxo-ethyl]-4-hydroxy-2-oxo-1H-quinoline-6-carboxamide, ... (6 entities in total)
Functional Keywords	hydrolase, serine protease
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Secreted: P03951
Total number of polymer chains	1
Total formula weight	28357.88
Authors	Sandmark, J.,Oster, L.,Jacso, T.,Ullah, V.,Redzick, A.,Borjesson, U.,Olsson, T.,Norberg, M.,Akerud, T. (deposition date: 2014-11-24, release date: 2016-01-20, Last modification date: 2024-10-23)
Primary citation	Jacso, T.,Ullah, V.,Sandmark, J.,Oster, L.,Redzick, A.,Borjesson, U.,Olsson, T.,Akerud, T. From Mm Fragments to Nm Compounds Using Iloe-NMR to Guide Linking of Compounds in Fragment Based Drug Discovery (Fbdd). To be Published,
Experimental method	X-RAY DIFFRACTION (2.33 Å)

Structure validation