4D7F
Human FXIa in complex with small molecule inhibitors.
Summary for 4D7F
Entry DOI | 10.2210/pdb4d7f/pdb |
Related | 4D76 4D7G |
Descriptor | COAGULATION FACTOR XI, GLYCEROL, N-[(2S)-1-({4-[(diaminomethylidene)amino]butyl}amino)-1-oxo-3-phenylpropan-2-yl]-4-hydroxy-2-oxo-1,2-dihydroquinoline-6-carboxamide, ... (5 entities in total) |
Functional Keywords | hydrolase, serine protease |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Secreted: P03951 |
Total number of polymer chains | 1 |
Total formula weight | 27693.23 |
Authors | Sandmark, J.,Oster, L.,Jacso, T.,Ullah, V.,Redzick, A.,Borjesson, U.,Olsson, T.,Norberg, M.,Akerud, T. (deposition date: 2014-11-24, release date: 2016-01-20) |
Primary citation | Jacso, T.,Ullah, V.,Sandmark, J.,Oster, L.,Redzick, A.,Borjesson, U.,Olsson, T.,Akerud, T. From Mm Fragments to Nm Compounds Using Iloe-NMR to Guide Linking of Compounds in Fragment Based Drug Discovery (Fbdd). To be Published, |
Experimental method | X-RAY DIFFRACTION (1.62 Å) |
Structure validation
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