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4D76

Human FXIa in complex with small molecule inhibitors.

Summary for 4D76
Entry DOI10.2210/pdb4d76/pdb
Related4D7F 4D7G
DescriptorCOAGULATION FACTOR XI, GLYCEROL, N-[(2S)-1-({5-[(diaminomethylidene)amino]pentyl}amino)-1-oxo-3-phenylpropan-2-yl]-4-hydroxy-2-oxo-1,2-dihydroquinoline-6-carboxamide, ... (5 entities in total)
Functional Keywordshydrolase, serine protease
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationSecreted: P03951
Total number of polymer chains1
Total formula weight27795.38
Authors
Sandmark, J.,Oster, L.,Jacso, T.,Ullah, V.,Redzick, A.,Borjesson, U.,Olsson, T.,Norberg, M.,Akerud, T. (deposition date: 2014-11-20, release date: 2016-01-20)
Primary citationJacso, T.,Ullah, V.,Sandmark, J.,Oster, L.,Redzick, A.,Borjesson, U.,Olsson, T.,Akerud, T.
From Mm Fragments to Nm Compounds Using Iloe-NMR to Guide Linking of Compounds in Fragment Based Drug Discovery (Fbdd).
To be Published,
Experimental method
X-RAY DIFFRACTION (1.77 Å)
Structure validation

217705

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