4D76

Human FXIa in complex with small molecule inhibitors.

Summary for 4D76

• Entry DOI: 10.2210/pdb4d76/pdb
• Related: 4D7F 4D7G
• Descriptor: COAGULATION FACTOR XI, GLYCEROL, N-[(2S)-1-({5-[(diaminomethylidene)amino]pentyl}amino)-1-oxo-3-phenylpropan-2-yl]-4-hydroxy-2-oxo-1,2-dihydroquinoline-6-carboxamide, ... (5 entities in total)
• Functional Keywords: hydrolase, serine protease
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Secreted: P03951
• Total number of polymer chains: 1
• Total formula weight: 27795.38

Authors

Sandmark, J.,Oster, L.,Jacso, T.,Ullah, V.,Redzick, A.,Borjesson, U.,Olsson, T.,Norberg, M.,Akerud, T. (deposition date: 2014-11-20, release date: 2016-01-20, Last modification date: 2024-11-13)

• Primary citation: Jacso, T.,Ullah, V.,Sandmark, J.,Oster, L.,Redzick, A.,Borjesson, U.,Olsson, T.,Akerud, T.; From Mm Fragments to Nm Compounds Using Iloe-NMR to Guide Linking of Compounds in Fragment Based Drug Discovery (Fbdd).; To be Published,

Experimental method

X-RAY DIFFRACTION (1.77 Å)