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4D6G

Crystal structure of a family 98 glycoside hydrolase catalytic module (Sp3GH98) in complex with the blood group A-trisaccharide (L19 mutant)

Summary for 4D6G
Entry DOI10.2210/pdb4d6g/pdb
Related4D6C 4D6D 4D6E 4D6F 4D6H 4D6I 4D6J
DescriptorGLYCOSIDE HYDROLASE, alpha-L-fucopyranose-(1-2)-[2-acetamido-2-deoxy-alpha-D-galactopyranose-(1-3)]alpha-D-galactopyranose, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywordshydrolase, blood group antigen
Biological sourceSTREPTOCOCCUS PNEUMONIAE
Total number of polymer chains1
Total formula weight69660.14
Authors
Kwan, D.H.,Constantinescu, I.,Chapanian, R.,Higgins, M.A.,Samain, E.,Boraston, A.B.,Kizhakkedathu, J.N.,Withers, S.G. (deposition date: 2014-11-11, release date: 2014-11-26, Last modification date: 2023-12-20)
Primary citationKwan, D.H.,Constantinescu, I.,Chapanian, R.,Higgins, M.A.,Koetzler, M.,Samain, E.,Boraston, A.B.,Kizhakkedathu, J.N.,Withers, S.G.
Towards Efficient Enzymes for the Generation of Universal Blood Through Structure-Guided Directed Evolution.
J.Am.Chem.Soc., 137:5695-, 2015
Cited by
PubMed: 25870881
DOI: 10.1021/JA5116088
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.24 Å)
Structure validation

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