4D4M

human PFKFB3 in complex with a pyrrolopyrimidone compound

Summary for 4D4M

• Entry DOI: 10.2210/pdb4d4m/pdb
• Related: 4D4J 4D4K 4D4L
• Descriptor: 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE 3, PHOSPHATE ION, PHOSPHONIC ACID, ... (6 entities in total)
• Functional Keywords: transferase, sugar kinase, warburg effect, oncology
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 1
• Total formula weight: 52964.74

Authors

Stgallay, S.A.,Bennett, N.,Critchlow, S.,Davies, G.,Debreczeni, J.E.,Evans, N.,Holdgate, G.,Jones, N.P.,Leach, L.,Maman, S.,McLoughlin, S.,Preston, M.,Rigoreau, L.,Thomas, A.,Walker, G.,Walsch, J.,Ward, R.A.,Wheatley, E.,Winter, J. (deposition date: 2014-10-29, release date: 2016-01-20, Last modification date: 2024-05-08)

• Primary citation: Stgallay, S.A.,Bennett, N.,Critchlow, S.,Davies, G.,Debreczeni, J.E.,Evans, N.,Holdgate, G.,Jones, N.P.,Leach, L.,Maman, S.,Mcloughlin, S.,Preston, M.,Rigoreau, L.,Thomas, A.,Walker, G.,Walsch, J.,Ward, R.A.,Wheatley, E.,Winter, J.; Identifying a Novel Series of Pfkfb3 Inhibitors as a Metabolic Approach to Treating Cancer from Hts, Biophysical and Biochemical Methods; To be Published,

Experimental method

X-RAY DIFFRACTION (2.32 Å)