4D4K

human PFKFB3 in complex with a pyrrolopyrimidone compound

4D4K の概要

• エントリーDOI: 10.2210/pdb4d4k/pdb
• 関連するPDBエントリー: 4D4J 4D4L 4D4M
• 分子名称: 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE 3, PHOSPHONIC ACID, PHOSPHATE ION, ... (6 entities in total)
• 機能のキーワード: transferase, sugar kinase, warburg effect, oncology
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 52820.90

構造登録者

Stgallay, S.A.,Bennett, N.,Critchlow, S.,Davies, G.,Debreczeni, J.E.,Evans, N.,Holdgate, G.,Jones, N.P.,Leach, L.,Maman, S.,McLoughlin, S.,Preston, M.,Rigoreau, L.,Thomas, A.,Walker, G.,Walsch, J.,Ward, R.A.,Wheatley, E.,Winter, J. (登録日: 2014-10-29, 公開日: 2016-01-20, 最終更新日: 2020-07-29)

• 主引用文献: Stgallay, S.A.,Bennett, N.,Critchlow, S.,Davies, G.,Debreczeni, J.E.,Evans, N.,Holdgate, G.,Jones, N.P.,Leach, L.,Maman, S.,Mcloughlin, S.,Preston, M.,Rigoreau, L.,Thomas, A.,Walker, G.,Walsch, J.,Ward, R.A.,Wheatley, E.,Winter, J.; Identifying a Novel Series of Pfkfb3 Inhibitors as a Metabolic Approach to Treating Cancer from Hts, Biophysical and Biochemical Methods; To be Published,

実験手法

X-RAY DIFFRACTION (3.24 Å)