4D46

Crystal structure of E. coli FabI in complex with NAD and 5-bromo-2-(4-chloro-2-hydroxyphenoxy)benzonitrile

Summary for 4D46

Entry DOI	10.2210/pdb4d46/pdb
Related	4D41 4D42 4D43 4D44 4D45
Descriptor	ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 5-bromo-2-(4-chloro-2-hydroxyphenoxy)benzonitrile, ... (4 entities in total)
Functional Keywords	enoyl-acp reductase, short-chain dehydrogenase/reductase superfamily, escherichia coli, fatty acid biosynthesis, lipid synthesis, ecfabi, fabi, oxidoreductase
Biological source	ESCHERICHIA COLI
Total number of polymer chains	2
Total formula weight	59904.10
Authors	Tareilus, M.,Schiebel, J.,Chang, A.,Tonge, P.J.,Sotriffer, C.A.,Kisker, C. (deposition date: 2014-10-26, release date: 2015-03-04, Last modification date: 2023-12-20)
Primary citation	Schiebel, J.,Chang, A.,Merget, B.,Bommineni, G.R.,Yu, W.,Spagnuolo, L.A.,Baxter, M.V.,Tareilus, M.,Tonge, P.J.,Kisker, C.,Sotriffer, C.A. An Ordered Water Channel in Staphylococcus Aureus Fabi: Unraveling the Mechanism of Substrate Recognition and Reduction. Biochemistry, 54:1943-, 2015 Cited by PubMed: 25706582 DOI: 10.1021/BI5014358 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation