4D44
Crystal structure of S. aureus FabI in complex with NADP and 5-ethyl- 4-fluoro-2-((2-fluoropyridin-3-yl)oxy)phenol
Summary for 4D44
Entry DOI | 10.2210/pdb4d44/pdb |
Related | 4D41 4D42 4D43 4D45 4D46 |
Descriptor | ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADPH], NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (4R)-2-METHYLPENTANE-2,4-DIOL, ... (6 entities in total) |
Functional Keywords | oxidoreductase, short-chain dehydrogenase/reductase superfamily, fatty acid biosynthesis, lipid synthesis, safabi, fabi |
Biological source | STAPHYLOCOCCUS AUREUS SUBSP. AUREUS N315 |
Total number of polymer chains | 8 |
Total formula weight | 258939.16 |
Authors | Schiebel, J.,Chang, A.,Tonge, P.J.,Sotriffer, C.A.,Kisker, C. (deposition date: 2014-10-26, release date: 2015-03-04, Last modification date: 2023-12-20) |
Primary citation | Schiebel, J.,Chang, A.,Merget, B.,Bommineni, G.R.,Yu, W.,Spagnuolo, L.A.,Baxter, M.V.,Tareilus, M.,Tonge, P.J.,Kisker, C.,Sotriffer, C.A. An Ordered Water Channel in Staphylococcus Aureus Fabi: Unraveling the Mechanism of Substrate Recognition and Reduction. Biochemistry, 54:1943-, 2015 Cited by PubMed: 25706582DOI: 10.1021/BI5014358 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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