4D0S
Mtb InhA complex with Pyradizinone compound 14
Summary for 4D0S
Entry DOI | 10.2210/pdb4d0s/pdb |
Related | 4D0R |
Descriptor | ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 1-{4-[(acetylamino)methyl]phenyl}-4-(4-chlorophenoxy)-6-oxo-1,6-dihydropyridazine-3-carboxamide, ... (5 entities in total) |
Functional Keywords | oxidoreductase, inha, acp enoyl reductase, methyl-thiazole |
Biological source | MYCOBACTERIUM TUBERCULOSIS |
Total number of polymer chains | 4 |
Total formula weight | 118572.74 |
Authors | Read, J.A.,Breed, J.,Madhavapeddi, P.,Lange, S. (deposition date: 2014-04-29, release date: 2015-05-20, Last modification date: 2023-12-20) |
Primary citation | Lange, S. Pyridazinones: A Novel Scaffold with Excellent Physicochemical Properties and Safety Profile for a Clinically Validated Target of Mycobacterium Tuberculosis To be Published, |
Experimental method | X-RAY DIFFRACTION (1.64 Å) |
Structure validation
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