4CXM

Crystal Structure of Plasmodium Falciparum Spermidine Synthase in Complex with METHYLTHIOADENOSIN AND SPERMIDINE after catalysis in crystal

Summary for 4CXM

• Entry DOI: 10.2210/pdb4cxm/pdb
• Related: 4CWA
• Descriptor: SPERMIDINE SYNTHASE, 5'-DEOXY-5'-METHYLTHIOADENOSINE, SPERMIDINE, ... (4 entities in total)
• Functional Keywords: transferase, aninopropyl transferase, polyamine pathway. rossmann-like fold
• Biological source: PLASMODIUM FALCIPARUM
• Total number of polymer chains: 3
• Total formula weight: 97991.19

Authors

Sprenger, J.,Svensson, B.,Al-Karadaghi, S.,Persson, L. (deposition date: 2014-04-07, release date: 2014-10-08, Last modification date: 2023-12-20)

• Primary citation: Sprenger, J.,Svensson, B.,Halander, J.,Carey, J.,Persson, L.,Al-Karadaghi, S.; Three-Dimensional Structures of Plasmodium Falciparum Spermidine Synthase with Bound Inhibitors Suggest New Strategies for Drug Design.; Acta Crystallogr.,Sect.D, 71:484-, 2015; PubMed: 25760598; DOI: 10.1107/S1399004714027011

Experimental method

X-RAY DIFFRACTION (1.75 Å)