4CVY

Crystal structure of the M. tuberculosis sulfate ester dioxygenase Rv3406 in complex with iron.

Summary for 4CVY

Entry DOI	10.2210/pdb4cvy/pdb
Descriptor	DIOXYGENASE RV3406/MT3514, NITRATE ION, FE (III) ION, ... (4 entities in total)
Functional Keywords	oxidoreductase, drug design, dioxygenase, dpre1, mycobacterial enzymes
Biological source	MYCOBACTERIUM TUBERCULOSIS
Total number of polymer chains	4
Total formula weight	130760.81
Authors	Neres, J.,Hartkoorn, R.C.,Chiarelli, L.R.,Gadupudi, R.,Pasca, M.,Mori, G.,Farina, D.,Salina, S.,Makarov, V.,Kolly, G.S.,Molteni, E.,Binda, C.,Dhar, N.,Ferrari, S.,Brodin, P.,Delorme, V.,Landry, V.,de Jesus Lopes Ribeiro, A.L.,Saxena, P.,Pojer, F.,Venturelli, A.,Carta, A.,Luciani, R.,Porta, A.,Zanoni, G.,De Rossi, E.,Costi, M.P.,Riccardi, G.,Cole, S.T. (deposition date: 2014-03-31, release date: 2014-12-10, Last modification date: 2023-12-20)
Primary citation	Neres, J.,Hartkoorn, R.C.,Chiarelli, L.R.,Gadupudi, R.,Pasca, M.R.,Mori, G.,Venturelli, A.,Savina, S.,Makarov, V.,Kolly, G.S.,Molteni, E.,Binda, C.,Dhar, N.,Ferrari, S.,Brodin, P.,Delorme, V.,Landry, V.,De Jesus Lopes Ribeiro, A.L.,Farina, D.,Saxena, P.,Pojer, F.,Carta, A.,Luciani, R.,Porta, A.,Zanoni, G.,De Rossi, E.,Costi, M.P.,Riccardi, G.,Cole, S.T. 2-Carboxyquinoxalines Kill Mycobacterium Tuberculosis Through Noncovalent Inhibition of Dpre1. Acs Chem.Biol., 10:705-, 2015 Cited by PubMed: 25427196 DOI: 10.1021/CB5007163 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation