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4CV3

Crystal structure of E. coli FabI in complex with NADH and PT166

Summary for 4CV3
Entry DOI10.2210/pdb4cv3/pdb
Related4CUZ 4CV0 4CV1 4CV2
DescriptorENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH], 2-hexyl-1-methyl-5-(2-methylphenoxy)pyridin-4(1H)-one, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ... (4 entities in total)
Functional Keywordsshort-chain dehydrogenase/reductase superfamily, fatty acid biosynthesis, lipid synthesis, ecfabi, oxidoreductase
Biological sourceESCHERICHIA COLI
Total number of polymer chains2
Total formula weight59857.83
Authors
Eltschkner, S.,Schiebel, J.,Chang, A.,Shah, S.,Tonge, P.J.,Kisker, C. (deposition date: 2014-03-22, release date: 2014-04-16, Last modification date: 2023-12-20)
Primary citationSchiebel, J.,Chang, A.,Shah, S.,Lu, Y.,Liu, L.,Pan, P.,Hirschbeck, M.W.,Tareilus, M.,Eltschkner, S.,Yu, W.,Cummings, J.E.,Knudson, S.E.,Bommineni, G.R.,Walker, S.G.,Slayden, R.A.,Sotriffer, C.A.,Tonge, P.J.,Kisker, C.
Rational Design of Broad Spectrum Antibacterial Activity Based on a Clinically Relevant Enoyl-Acyl Carrier Protein (Acp) Reductase Inhibitor.
J.Biol.Chem., 289:15987-, 2014
Cited by
PubMed: 24739388
DOI: 10.1074/JBC.M113.532804
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.95 Å)
Structure validation

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