4CV3
Crystal structure of E. coli FabI in complex with NADH and PT166
Summary for 4CV3
Entry DOI | 10.2210/pdb4cv3/pdb |
Related | 4CUZ 4CV0 4CV1 4CV2 |
Descriptor | ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH], 2-hexyl-1-methyl-5-(2-methylphenoxy)pyridin-4(1H)-one, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ... (4 entities in total) |
Functional Keywords | short-chain dehydrogenase/reductase superfamily, fatty acid biosynthesis, lipid synthesis, ecfabi, oxidoreductase |
Biological source | ESCHERICHIA COLI |
Total number of polymer chains | 2 |
Total formula weight | 59857.83 |
Authors | Eltschkner, S.,Schiebel, J.,Chang, A.,Shah, S.,Tonge, P.J.,Kisker, C. (deposition date: 2014-03-22, release date: 2014-04-16, Last modification date: 2023-12-20) |
Primary citation | Schiebel, J.,Chang, A.,Shah, S.,Lu, Y.,Liu, L.,Pan, P.,Hirschbeck, M.W.,Tareilus, M.,Eltschkner, S.,Yu, W.,Cummings, J.E.,Knudson, S.E.,Bommineni, G.R.,Walker, S.G.,Slayden, R.A.,Sotriffer, C.A.,Tonge, P.J.,Kisker, C. Rational Design of Broad Spectrum Antibacterial Activity Based on a Clinically Relevant Enoyl-Acyl Carrier Protein (Acp) Reductase Inhibitor. J.Biol.Chem., 289:15987-, 2014 Cited by PubMed: 24739388DOI: 10.1074/JBC.M113.532804 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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