4CV1

Crystal structure of S. aureus FabI in complex with NADPH and CG400549

Summary for 4CV1

Entry DOI	10.2210/pdb4cv1/pdb
Related	4CUZ 4CV0 4CV2 4CV3
Descriptor	ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH], SULFATE ION, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (7 entities in total)
Functional Keywords	enoyl-acp reductase, short-chain dehydrogenase/reductase superfamily, fatty acid biosynthesis, lipid synthesis, safabi, oxidoreductase
Biological source	ESCHERICHIA COLI
Total number of polymer chains	8
Total formula weight	258791.04
Authors	Schiebel, J.,Chang, A.,Shah, S.,Tonge, P.J.,Kisker, C. (deposition date: 2014-03-22, release date: 2014-04-16, Last modification date: 2023-12-20)
Primary citation	Schiebel, J.,Chang, A.,Shah, S.,Lu, Y.,Liu, L.,Pan, P.,Hirschbeck, M.W.,Tareilus, M.,Eltschkner, S.,Yu, W.,Cummings, J.E.,Knudson, S.E.,Bommineni, G.R.,Walker, S.G.,Slayden, R.A.,Sotriffer, C.A.,Tonge, P.J.,Kisker, C. Rational Design of Broad Spectrum Antibacterial Activity Based on a Clinically Relevant Enoyl-Acyl Carrier Protein (Acp) Reductase Inhibitor. J.Biol.Chem., 289:15987-, 2014 Cited by PubMed: 24739388 DOI: 10.1074/JBC.M113.532804 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation