4CSY

E-selectin lectin, EGF-like and two SCR domains complexed with Sialyl Lewis X

4CSY の概要

• エントリーDOI: 10.2210/pdb4csy/pdb
• 関連するPDBエントリー: 4CSS 4CST
• 分子名称: E-SELECTIN, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)]methyl 2-acetamido-2-deoxy-beta-D-glucopyranoside, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: cell-adhesion, human lectin, c-type lectin, inflammation, leukocyte, sialyl lewis x, slex, protein conformation, ligand-induced conformational change, catch- bond, cell adhesion
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Cell membrane ; Single-pass type I membrane protein: P16581
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 67458.13

構造登録者

Preston, R.C.,Jakob, R.P.,Binder, F.P.C.,Sager, C.P.,Ernst, B.,Maier, T. (登録日: 2014-03-11, 公開日: 2014-09-24, 最終更新日: 2023-12-20)

• 主引用文献: Preston, R.C.,Jakob, R.P.,Binder, F.P.,Sager, C.P.,Ernst, B.,Maier, T.; E-Selectin Ligand Complexes Adopt an Extended High-Affinity Conformation.; J.Mol.Cell.Biol., 8:62-, 2016; PubMed: 26117840; DOI: 10.1093/JMCB/MJV046

実験手法

X-RAY DIFFRACTION (2.41 Å)