4CRT
Crystal structure of human monoamine oxidase B in complex with the multi-target inhibitor ASS234
Summary for 4CRT
Entry DOI | 10.2210/pdb4crt/pdb |
Descriptor | AMINE OXIDASE [FLAVIN-CONTAINING] B, FLAVIN-ADENINE DINUCLEOTIDE, (E)-N-methyl-N-[[1-methyl-5-[3-[1-(phenylmethyl)piperidin-4-yl]propoxy]indol-2-yl]methyl]prop-1-en-1-amine, ... (4 entities in total) |
Functional Keywords | oxidoreductase, enzyme, flavin, drug design, alzheimer's disease |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side: P27338 |
Total number of polymer chains | 2 |
Total formula weight | 120137.84 |
Authors | Esteban, G.,Allan, J.,Samadi, A.,Mattevi, A.,Unzeta, M.,Marco-Contelles, J.,Binda, C.,Ramsay, R.R. (deposition date: 2014-02-28, release date: 2014-04-02, Last modification date: 2014-05-07) |
Primary citation | Esteban, G.,Allan, J.,Samadi, A.,Mattevi, A.,Unzeta, M.,Marco-Contelles, J.,Binda, C.,Ramsay, R.R. Kinetic and Structural Analysis of the Irreversible Inhibition of Human Monoamine Oxidases by Ass234, a Multi-Target Compound Designed for Use in Alzheimer'S Disease. Biochim.Biophys.Acta, 1844:1104-, 2014 Cited by PubMed: 24642166DOI: 10.1016/J.BBAPAP.2014.03.006 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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