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4CRT

Crystal structure of human monoamine oxidase B in complex with the multi-target inhibitor ASS234

Summary for 4CRT
Entry DOI10.2210/pdb4crt/pdb
DescriptorAMINE OXIDASE [FLAVIN-CONTAINING] B, FLAVIN-ADENINE DINUCLEOTIDE, (E)-N-methyl-N-[[1-methyl-5-[3-[1-(phenylmethyl)piperidin-4-yl]propoxy]indol-2-yl]methyl]prop-1-en-1-amine, ... (4 entities in total)
Functional Keywordsoxidoreductase, enzyme, flavin, drug design, alzheimer's disease
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationMitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side: P27338
Total number of polymer chains2
Total formula weight120137.84
Authors
Esteban, G.,Allan, J.,Samadi, A.,Mattevi, A.,Unzeta, M.,Marco-Contelles, J.,Binda, C.,Ramsay, R.R. (deposition date: 2014-02-28, release date: 2014-04-02, Last modification date: 2014-05-07)
Primary citationEsteban, G.,Allan, J.,Samadi, A.,Mattevi, A.,Unzeta, M.,Marco-Contelles, J.,Binda, C.,Ramsay, R.R.
Kinetic and Structural Analysis of the Irreversible Inhibition of Human Monoamine Oxidases by Ass234, a Multi-Target Compound Designed for Use in Alzheimer'S Disease.
Biochim.Biophys.Acta, 1844:1104-, 2014
Cited by
PubMed: 24642166
DOI: 10.1016/J.BBAPAP.2014.03.006
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.8 Å)
Structure validation

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