4CRP
Solution structure of a TrkAIg2 domain construct for use in drug discovery
Summary for 4CRP
Entry DOI | 10.2210/pdb4crp/pdb |
NMR Information | BMRB: 19824 |
Descriptor | HIGH AFFINITY NERVE GROWTH FACTOR RECEPTOR (1 entity in total) |
Functional Keywords | transferase, trkaig2, nmr construct, pain, alzheimers |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cell membrane ; Single-pass type I membrane protein : P04629 |
Total number of polymer chains | 1 |
Total formula weight | 11792.07 |
Authors | Shoemark, D.K.,Fahey, M.,Williams, C.,Sessions, R.B.,Crump, M.P.,Allen-Birt, S.J. (deposition date: 2014-02-28, release date: 2015-01-14, Last modification date: 2023-06-14) |
Primary citation | Allen, S.J.,Watson, J.J.,Shoemark, D.K.,Barua, N.U.,Patel, N.K. Design and Nuclear Magnetic Resonance (NMR) Structure Determination of the Second Extracellular Immunoglobulin Tyrosine Kinase a (Trkaig2) Domain Construct for Binding Site Elucidation in Drug Discovery J.Med.Chem., 58:767-, 2015 Cited by PubMed: 25454499DOI: 10.1021/JM501307E PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
Download full validation report