4CRP

Solution structure of a TrkAIg2 domain construct for use in drug discovery

4CRP の概要

• エントリーDOI: 10.2210/pdb4crp/pdb
• NMR情報: BMRB: 19824
• 分子名称: HIGH AFFINITY NERVE GROWTH FACTOR RECEPTOR (1 entity in total)
• 機能のキーワード: transferase, trkaig2, nmr construct, pain, alzheimers
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Cell membrane ; Single-pass type I membrane protein : P04629
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 11792.07

構造登録者

Shoemark, D.K.,Fahey, M.,Williams, C.,Sessions, R.B.,Crump, M.P.,Allen-Birt, S.J. (登録日: 2014-02-28, 公開日: 2015-01-14, 最終更新日: 2023-06-14)

• 主引用文献: Allen, S.J.,Watson, J.J.,Shoemark, D.K.,Barua, N.U.,Patel, N.K.; Design and Nuclear Magnetic Resonance (NMR) Structure Determination of the Second Extracellular Immunoglobulin Tyrosine Kinase a (Trkaig2) Domain Construct for Binding Site Elucidation in Drug Discovery; J.Med.Chem., 58:767-, 2015; PubMed: 25454499; DOI: 10.1021/JM501307E

実験手法

SOLUTION NMR