4CRL

Crystal structure of human CDK8-Cyclin C in complex with cortistatin A

4CRL の概要

• エントリーDOI: 10.2210/pdb4crl/pdb
• 分子名称: CYCLIN-DEPENDENT KINASE 8, CYCLIN-C, CORTISTATIN A, ... (5 entities in total)
• 機能のキーワード: transferase, cyclin-dependent kinase 8, cdk8, cyclin c, ccnc, cortistatin a, mediator kinase, mediator complex, super-enhancer, transcription
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 81288.58

構造登録者

Myers, A.G.,Shair, M.D. (登録日: 2014-02-27, 公開日: 2015-09-23, 最終更新日: 2023-12-20)

• 主引用文献: Pelish, H.E.,Liau, B.B.,Nitulescu, I.I.,Tangpeerachaikul, A.,Poss, Z.C.,Da Silva, D.H.,Caruso, B.T.,Arefolov, A.,Fadeyi, O.,Christie, A.L.,Du, K.,Banka, D.,Schneider, E.V.,Jestel, A.,Zou, G.,Si, C.,Ebmeier, C.C.,Bronson, R.T.,Krivtsov, A.V.,Myers, A.G.,Kohl, N.E.,Kung, A.L.,Armstrong, S.A.,Lemieux, M.E.,Taatjes, D.J.,Shair, M.D.; Mediator Kinase Inhibition Further Activates Super-Enhancer- Associated Genes in Aml; Nature, 526:273-, 2015; PubMed: 26416749; DOI: 10.1038/NATURE14904

実験手法

X-RAY DIFFRACTION (2.4 Å)