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4CR5

Creating novel F1 inhibitors through fragment based lead generation and structure aided drug design

Summary for 4CR5
Entry DOI10.2210/pdb4cr5/pdb
DescriptorCOAGULATION FACTOR XIA, 6-chloroquinolin-2(1H)-one, SULFATE ION, ... (4 entities in total)
Functional Keywordshydrolase
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationSecreted: P03951
Total number of polymer chains1
Total formula weight27604.41
Authors
Primary citationFjellstrom, O.,Akkaya, S.,Beisel, H.,Eriksson, P.,Erixon, K.,Gustafsson, D.,Jurva, U.,Kang, D.,Karis, D.,Knecht, W.,Nerme, V.,Nilsson, I.,Olsson, T.,Redzic, A.,Roth, R.,Sandmark, J.,Tigerstrom, A.,Oster, L.
Creating Novel Activated Factor Xi Inhibitors Through Fragment Based Lead Generation and Structure Aided Drug Design.
Plos One, 10:13705-, 2015
Cited by
PubMed: 25629509
DOI: 10.1371/JOURNAL.PONE.0113705
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

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