4CQ8
Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) in complex with Genz-669178
Summary for 4CQ8
Entry DOI | 10.2210/pdb4cq8/pdb |
Related | 4CQ9 4CQA |
Descriptor | DIHYDROOROTATE DEHYDROGENASE, FLAVIN MONONUCLEOTIDE, OROTIC ACID, ... (5 entities in total) |
Functional Keywords | oxidoreductase, dhodh |
Biological source | PLASMODIUM FALCIPARUM |
Total number of polymer chains | 2 |
Total formula weight | 92641.48 |
Authors | Rowland, P. (deposition date: 2014-02-12, release date: 2014-04-30, Last modification date: 2024-05-08) |
Primary citation | Ross, L.S.,Javier Gamo, F.,Lafuente-Monasterio, M.J.E.,Singh, O.M.P.,Rowland, P.,Wiegand, R.C.,Wirth, D.F. In Vitro Resistance Selections for Plasmodium Falciparum Dihydroorotate Dehydrogenase Inhibitors Give Mutants with Multiple Point Mutations in the Drug-Binding Site and Altered Growth. J.Biol.Chem., 289:17980-, 2014 Cited by PubMed: 24782313DOI: 10.1074/JBC.M114.558353 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.98 Å) |
Structure validation
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