4CQ8
Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) in complex with Genz-669178
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | DIHYDROOROTATE DEHYDROGENASE | polymer | 401 | 45385.9 | 2 | UniProt (Q54A96) Pfam (PF01180) UniProt (by SIFTS) (Q08210) In PDB | PLASMODIUM FALCIPARUM | |
2 | A, B | FLAVIN MONONUCLEOTIDE | non-polymer | 456.3 | 2 | Chemie (FMN) | |||
3 | A, B | OROTIC ACID | non-polymer | 156.1 | 2 | Chemie (ORO) | |||
4 | A, B | 5-(4-cyano-2-methyl-1H-benzimidazol-1-yl)-N-cyclopropylthiophene-2-carboxamide | non-polymer | 322.4 | 2 | Chemie (JBW) | |||
5 | water | water | 18.0 | 568 | Chemie (HOH) |
Sequence modifications
A, B: 158 - 383 (UniProt: Q54A96)
PDB | External Database | Details |
---|---|---|
Met 139 | - | expression tag |
Gly 140 | - | expression tag |
His 141 | - | expression tag |
His 142 | - | expression tag |
His 143 | - | expression tag |
His 144 | - | expression tag |
His 145 | - | expression tag |
His 146 | - | expression tag |
Ala 147 | - | expression tag |
Glu 148 | - | expression tag |
Asn 149 | - | expression tag |
Leu 150 | - | expression tag |
Tyr 151 | - | expression tag |
Phe 152 | - | expression tag |
Gln 153 | - | expression tag |
Gly 154 | - | expression tag |
Ala 155 | - | expression tag |
Asp 156 | - | expression tag |
Pro 157 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 90771.8 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 1869.6 | |
All* | Total formula weight | 92641.5 |