4CNI

Crystal structure of the Fab portion of Olokizumab in complex with IL- 6

Summary for 4CNI

Entry DOI	10.2210/pdb4cni/pdb
Descriptor	OLOKIZUMAB HEAVY CHAIN, FAB PORTION, OLOKIZUMAB LIGHT CHAIN, FAB PORTION, INTERLEUKIN-6, ... (6 entities in total)
Functional Keywords	immune system, cdp6038, interleukin 6
Biological source	HOMO SAPIENS (HUMAN) More
Total number of polymer chains	6
Total formula weight	134590.49
Authors	Shaw, S.,Bourne, T.,Meier, C.,Carrington, B.,Gelinas, R.,Henry, A.,Popplewell, A.,Adams, R.,Baker, T.,Rapecki, S.,Marshall, D.,Neale, H.,Lawson, A. (deposition date: 2014-01-22, release date: 2014-04-30, Last modification date: 2019-04-03)
Primary citation	Shaw, S.,Bourne, T.,Meier, C.,Carrington, B.,Gelinas, R.,Henry, A.,Popplewell, A.,Adams, R.,Baker, T.,Rapecki, S.,Marshall, D.,Moore, A.,Neale, H.,Lawson, A. Discovery and Characterization of Olokizumab: A Humanized Antibody Targeting Interleukin-6 and Neutralizing Gp130-Signaling. Mabs, 6:773-, 2014 Cited by PubMed: 24670876 DOI: 10.4161/MABS.28612 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation