4CMM

Structure of human CD47 in complex with human Signal Regulatory Protein (SIRP) alpha v1

Summary for 4CMM

DescriptorTYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE SUBSTRATE 1, LEUKOCYTE SURFACE ANTIGEN CD47, N-ACETYL-D-GLUCOSAMINE, ... (4 entities in total)
Functional Keywordssignaling protein, paired receptor, immunological, inhibitory
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationMembrane; Single-pass type I membrane protein P78324
Cell membrane; Multi-pass membrane protein Q08722
Total number of polymer chains2
Total molecular weight29477.97
Authors
Hatherley, D.,Lea, S.M.,Johnson, S.,Barclay, A.N. (deposition date: 2014-01-16, release date: 2014-02-26, Last modification date: 2014-04-16)
Primary citation
Hatherley, D.,Lea, S.M.,Johnson, S.,Barclay, A.N.
Polymorphisms in the Human Inhibitory Signal-Regulatory Protein Alpha Do not Affect Binding to its Ligand Cd47.
J.Biol.Chem., 289:10024-, 2014
PubMed: 24550402 (PDB entries with the same primary citation)
DOI: 10.1074/JBC.M114.550558
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.92 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.230101.0%0.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution