4CLO
Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor and inhibitor
Summary for 4CLO
Entry DOI | 10.2210/pdb4clo/pdb |
Related | 4CL8 4CLD 4CLE 4CLH 4CLR |
Descriptor | PTERIDINE REDUCTASE 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-(phenylethynyl)-4-(pyrrolidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine, ... (6 entities in total) |
Functional Keywords | oxidoreductase, short-chain dehydrogenase/reductase |
Biological source | TRYPANOSOMA BRUCEI BRUCEI More |
Total number of polymer chains | 4 |
Total formula weight | 126990.31 |
Authors | |
Primary citation | Khalaf, A.I.,Huggan, J.K.,Suckling, C.J.,Gibson, C.L.,Stewart, K.,Giordani, F.,Barrett, M.P.,Wong, P.E.,Barrack, K.L.,Hunter, W.N. Structure-Based Design and Synthesis of Antiparasitic Pyrrolopyrimidines Targeting Pteridine Reductase 1. J.Med.Chem., 57:6479-, 2014 Cited by PubMed: 25007262DOI: 10.1021/JM500483B PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.88 Å) |
Structure validation
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