4CLB
N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH IBET-295
Summary for 4CLB
Entry DOI | 10.2210/pdb4clb/pdb |
Related | 4CL9 |
Descriptor | BROMODOMAIN-CONTAINING PROTEIN 4, 1,2-ETHANEDIOL, propan-2-yl N-[(2S,4R)-1-ethanoyl-2-methyl-6-[4-(methylaminomethyl)phenyl]-3,4-dihydro-2H-quinolin-4-yl]carbamate, ... (4 entities in total) |
Functional Keywords | transcription |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Nucleus: O60885 |
Total number of polymer chains | 1 |
Total formula weight | 15570.97 |
Authors | Chung, C.,Atkinson, S. (deposition date: 2014-01-13, release date: 2014-12-24, Last modification date: 2024-05-08) |
Primary citation | Atkinson, S.J.,Soden, P.E.,Angell, D.C.,Bantscheff, M.,Chung, C.,Giblin, K.A.,Smithers, N.,Furze, R.C.,Gordon, L.,Drewes, G.,Rioja, I.,Witherington, J.,Parr, N.J.,Prinjha, R.K. The Structure Based Design of Dual Hdac/Bet Inhibitors as Novel Epigenetic Probes. Medchemcomm, 5:342-, 2014 Cited by DOI: 10.1039/C3MD00285CPDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
Download full validation report