4CL6
Crystal Structure of 3-hydroxydecanoyl-Acyl Carrier Protein Dehydratase (FabA) from Pseudomonas aeruginosa in complex with N-(4- Chlorobenzyl)-3-(2-furyl)-1H-1,2,4-triazol-5-amine
Summary for 4CL6
Entry DOI | 10.2210/pdb4cl6/pdb |
Descriptor | 3-HYDROXYDECANOYL-[ACYL-CARRIER-PROTEIN] DEHYDRATASE, N-(4-chlorobenzyl)-5-(furan-2-yl)-1H-1,2,4-triazol-3-amine (3 entities in total) |
Functional Keywords | lyase, fatty acid biosynthesis, bacterial virulence, drug discovery |
Biological source | PSEUDOMONAS AERUGINOSA PAO1 |
Total number of polymer chains | 5 |
Total formula weight | 95216.19 |
Authors | Moynie, L.,McMahon, S.A.,Duthie, F.G.,Naismith, J.H. (deposition date: 2014-01-13, release date: 2015-01-21, Last modification date: 2023-12-20) |
Primary citation | Moynie, L.,Hope, A.G.,Finzel, K.,Schmidberger, J.,Leckie, S.M.,Schneider, G.,Burkart, M.D.,Smith, A.D.,Gray, D.W.,Naismith, J.H. A Substrate Mimic Allows High Throughput Assay of the Faba Protein and Consequently the Identification of a Novel Inhibitor of Pseudomonas Aeruginosa Faba. J.Mol.Biol., 428:108-120, 2016 Cited by PubMed: 26562505DOI: 10.1016/J.JMB.2015.10.027 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.41 Å) |
Structure validation
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