4CL6

Crystal Structure of 3-hydroxydecanoyl-Acyl Carrier Protein Dehydratase (FabA) from Pseudomonas aeruginosa in complex with N-(4- Chlorobenzyl)-3-(2-furyl)-1H-1,2,4-triazol-5-amine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0006629	biological_process	lipid metabolic process
A	0006631	biological_process	fatty acid metabolic process
A	0006633	biological_process	fatty acid biosynthetic process
A	0006636	biological_process	unsaturated fatty acid biosynthetic process
A	0008693	molecular_function	(3R)-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity
A	0016829	molecular_function	lyase activity
A	0016853	molecular_function	isomerase activity
A	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
A	0034017	molecular_function	trans-2-decenoyl-acyl-carrier-protein isomerase activity
B	0005737	cellular_component	cytoplasm
B	0006629	biological_process	lipid metabolic process
B	0006631	biological_process	fatty acid metabolic process
B	0006633	biological_process	fatty acid biosynthetic process
B	0006636	biological_process	unsaturated fatty acid biosynthetic process
B	0008693	molecular_function	(3R)-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity
B	0016829	molecular_function	lyase activity
B	0016853	molecular_function	isomerase activity
B	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
B	0034017	molecular_function	trans-2-decenoyl-acyl-carrier-protein isomerase activity
C	0005737	cellular_component	cytoplasm
C	0006629	biological_process	lipid metabolic process
C	0006631	biological_process	fatty acid metabolic process
C	0006633	biological_process	fatty acid biosynthetic process
C	0006636	biological_process	unsaturated fatty acid biosynthetic process
C	0008693	molecular_function	(3R)-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity
C	0016829	molecular_function	lyase activity
C	0016853	molecular_function	isomerase activity
C	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
C	0034017	molecular_function	trans-2-decenoyl-acyl-carrier-protein isomerase activity
D	0005737	cellular_component	cytoplasm
D	0006629	biological_process	lipid metabolic process
D	0006631	biological_process	fatty acid metabolic process
D	0006633	biological_process	fatty acid biosynthetic process
D	0006636	biological_process	unsaturated fatty acid biosynthetic process
D	0008693	molecular_function	(3R)-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity
D	0016829	molecular_function	lyase activity
D	0016853	molecular_function	isomerase activity
D	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
D	0034017	molecular_function	trans-2-decenoyl-acyl-carrier-protein isomerase activity
E	0005737	cellular_component	cytoplasm
E	0006629	biological_process	lipid metabolic process
E	0006631	biological_process	fatty acid metabolic process
E	0006633	biological_process	fatty acid biosynthetic process
E	0006636	biological_process	unsaturated fatty acid biosynthetic process
E	0008693	molecular_function	(3R)-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity
E	0016829	molecular_function	lyase activity
E	0016853	molecular_function	isomerase activity
E	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
E	0034017	molecular_function	trans-2-decenoyl-acyl-carrier-protein isomerase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE 7SB A 501

Chain	Residue
A	HIS70
B	GLY91
B	PHE92
B	GLY103
B	ARG104
B	ALA105
A	PHE71
A	GLY79
A	GLY115
A	HOH2046
B	GLN27
B	LEU28
B	TRP87
B	GLN88

---

site_id	AC2
Number of Residues	15
Details	BINDING SITE FOR RESIDUE 7SB B 501

Chain	Residue
A	GLN27
A	LEU28
A	TRP87
A	GLN88
A	GLY91
A	PHE92
A	GLY103
A	ARG104
A	ALA105
A	HOH2047
A	HOH2048
B	HIS70
B	PHE71
B	GLY79
B	GLY115

---

site_id	AC3
Number of Residues	16
Details	BINDING SITE FOR RESIDUE 7SB C 501

Chain	Residue
C	HIS70
C	PHE71
C	MET77
C	GLY79
C	GLY115
C	HOH2029
C	HOH2034
D	GLN27
D	LEU28
D	TRP87
D	GLN88
D	GLY91
D	PHE92
D	GLY103
D	ARG104
D	ALA105

---

site_id	AC4
Number of Residues	16
Details	BINDING SITE FOR RESIDUE 7SB D 501

Chain	Residue
C	GLN27
C	LEU28
C	TRP87
C	GLN88
C	GLY91
C	PHE92
C	GLY103
C	ARG104
C	ALA105
C	PHE171
C	HOH2035
D	HIS70
D	PHE71
D	MET77
D	GLY79
D	GLY115

---

site_id	AC5
Number of Residues	16
Details	BINDING SITE FOR RESIDUE 7SB E 501

Chain	Residue
E	GLN27
E	LEU28
E	HIS70
E	PHE71
E	MET77
E	GLY79
E	TRP87
E	GLN88
E	GLY91
E	PHE92
E	GLY103
E	ARG104
E	ALA105
E	GLY115
E	PHE171
E	HOH2030

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	ACT_SITE: ACT_SITE => ECO:0000250

Chain	Residue	Details
A	HIS70
B	HIS70
C	HIS70
D	HIS70
E	HIS70

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