4CKL
Structure of 55 kDa N-terminal domain of E. coli DNA gyrase A subunit with simocyclinone D8 bound
Summary for 4CKL
Entry DOI | 10.2210/pdb4ckl/pdb |
Related | 4CKK |
Descriptor | DNA GYRASE SUBUNIT A, SIMOCYCLINONE D8 (3 entities in total) |
Functional Keywords | isomerase, topoisomerase, antibiotic target |
Biological source | ESCHERICHIA COLI |
Cellular location | Cytoplasm (Potential): P0AES5 |
Total number of polymer chains | 2 |
Total formula weight | 111695.07 |
Authors | Hearnshaw, S.J.,Edwards, M.J.,Stevenson, C.E.M.,Lawson, D.M.,Maxwell, A. (deposition date: 2014-01-07, release date: 2014-03-12, Last modification date: 2023-12-20) |
Primary citation | Hearnshaw, S.J.,Edwards, M.J.,Stevenson, C.E.,Lawson, D.M.,Maxwell, A. A New Crystal Structure of the Bifunctional Antibiotic Simocyclinone D8 Bound to DNA Gyrase Gives Fresh Insight Into the Mechanism of Inhibition. J.Mol.Biol., 426:2023-, 2014 Cited by PubMed: 24594357DOI: 10.1016/J.JMB.2014.02.017 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
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