4CJX

The crystal structure of Trypanosoma brucei N5, N10- methylenetetrahydrofolate dehydrogenase-cyclohydrolase (FolD) complexed with NADP cofactor and inhibitor

4CJX の概要

• エントリーDOI: 10.2210/pdb4cjx/pdb
• 分子名称: C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC, PUTATIVE, GLYCEROL, DI(HYDROXYETHYL)ETHER, ... (6 entities in total)
• 機能のキーワード: oxidoreductase
• 由来する生物種: TRYPANOSOMA BRUCEI BRUCEI STRAIN 927/4 GUTAT10.1
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 70524.28

構造登録者

Eadsforth, T.C.,Hunter, W.N. (登録日: 2013-12-23, 公開日: 2015-02-04, 最終更新日: 2023-12-20)

• 主引用文献: Eadsforth, T.C.,Pinto, A.,Luciani, R.,Tamborini, L.,Cullia, G.,De Micheli, C.,Marinelli, L.,Cosconati, S.,Novellino, E.,Lo Presti, L.,Cordeiro Da Silva, A.,Conti, P.,Hunter, W.N.,Costi, M.P.; Characterization of 2,4-Diamino-6-Oxo-1,6-Dihydropyrimidin-5-Yl Ureido Based Inhibitors of Trypanosoma Brucei Fold and Testing for Antiparasitic Activity.; J.Med.Chem., 58:7938-, 2015; PubMed: 26322631; DOI: 10.1021/ACS.JMEDCHEM.5B00687

実験手法

X-RAY DIFFRACTION (2.05 Å)