4CIB

crystal structure of cathepsin a, complexed with compound 2

4CIB の概要

• エントリーDOI: 10.2210/pdb4cib/pdb
• 関連するPDBエントリー: 4CI9 4CIA
• 分子名称: LYSOSOMAL PROTECTIVE PROTEIN, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-(cyclohexylmethyl)propanedioic acid, ... (5 entities in total)
• 機能のキーワード: hydrolase, drug discovery, serine carboxypeptidase, cardiovascular drug, heart failure, endothelin, tetrahedral intermediate, covalent inhibitor
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 53440.45

構造登録者

Schreuder, H.A.,Liesum, A.,Kroll, K.,Boehnisch, B.,Buning, C.,Ruf, S.,Buning, C.,Sadowski, T. (登録日: 2013-12-06, 公開日: 2014-02-26, 最終更新日: 2023-12-20)

• 主引用文献: Schreuder, H.A.,Liesum, A.,Kroll, K.,Bohnisch, B.,Buning, C.,Ruf, S.,Sadowski, T.; Crystal structure of cathepsin A, a novel target for the treatment of cardiovascular diseases.; Biochem. Biophys. Res. Commun., 445:451-456, 2014; PubMed: 24530914; DOI: 10.1016/j.bbrc.2014.02.014

実験手法

X-RAY DIFFRACTION (1.89 Å)