4CIB

crystal structure of cathepsin a, complexed with compound 2

Summary for 4CIB

Entry DOI	10.2210/pdb4cib/pdb
Related	4CI9 4CIA
Descriptor	LYSOSOMAL PROTECTIVE PROTEIN, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-(cyclohexylmethyl)propanedioic acid, ... (5 entities in total)
Functional Keywords	hydrolase, drug discovery, serine carboxypeptidase, cardiovascular drug, heart failure, endothelin, tetrahedral intermediate, covalent inhibitor
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	1
Total formula weight	53440.45
Authors	Schreuder, H.A.,Liesum, A.,Kroll, K.,Boehnisch, B.,Buning, C.,Ruf, S.,Buning, C.,Sadowski, T. (deposition date: 2013-12-06, release date: 2014-02-26, Last modification date: 2023-12-20)
Primary citation	Schreuder, H.A.,Liesum, A.,Kroll, K.,Bohnisch, B.,Buning, C.,Ruf, S.,Sadowski, T. Crystal structure of cathepsin A, a novel target for the treatment of cardiovascular diseases. Biochem. Biophys. Res. Commun., 445:451-456, 2014 Cited by PubMed: 24530914 DOI: 10.1016/j.bbrc.2014.02.014 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.89 Å)

Structure validation